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HYDROCORTISONE‐INDUCED INHIBITOR OF PROSTAGLANDIN BIOSYNTHESIS IN RAT LEUCOCYTES
Author(s) -
CARNUCCIO ROSA,
ROSA M.,
PERSICO PAOLA
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10691.x
Subject(s) - cycloheximide , hydrocortisone , prostaglandin , protein synthesis inhibitor , endocrinology , chemistry , medicine , phospholipase a2 , biosynthesis , phospholipase , protein biosynthesis , pharmacology , biochemistry , biology , enzyme
Rat peritoneal leucocytes incubated with hydrocortisone (10 μg/ml) release a factor which inhibits prostaglandin generation. The steroid‐induced inhibitor, which mediates the anti‐phospholipase effect of anti‐inflammatory steroids, may be a protein or a polypeptide since its formation is blocked by cycloheximide, a known inhibitor of protein synthesis.