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EFFECT OF PROPRANOLOL ON β‐ADRENOCEPTORS IN RAT HEARTS
Author(s) -
BAKER STEPHEN P.,
POTTER LINCOLN T.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10689.x
Subject(s) - propranolol , dihydroalprenolol , adrenergic receptor , endocrinology , medicine , catecholamine , receptor , pharmacology , chemistry , antagonist , partial agonist
The question of whether the chronic administration of propranolol modifies the numbers or properties of cardiac β‐adrenoceptors was examined because of many reports suggestive of cardiac hypersensitivity following the withdrawal of β‐antagonists. In three studies, rats were given (±)‐propranolol, 30 mg/day, orally or intraperitoneally, for 1 to 7 weeks. The numbers and affinities of specific binding sites for radioactive dihydroalprenolol in whole hearts from 60 control and 75 test animals were found to be the same. Thus catecholamine deprivation does not exert an important regulatory effect on most β‐receptors in the heart, as it does in the brain.