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A CALCIUM‐DEPENDENT ACETYLCHOLINE DEPOLARIZATION BLOCKED BY METHOXYVERAPAMIL (D600) AND PROCAINE IN SNAIL NEURONES
Author(s) -
ISRAEL JEANMARC,
MEUNIER JEANMARIE
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10412.x
Subject(s) - depolarization , hexamethonium , acetylcholine , procaine , chemistry , atropine , calcium , biophysics , snail , medicine , endocrinology , neuroscience , biology , ecology , organic chemistry
1 Repetitive application of acetylcholine (ACh) revealed two types of ACh depolarization in two types of snail neurone, depending on their desensitization properties. 2 Further experiments were carried out on neurones which displayed a rapidly desensitizing response. 3 The amplitude of the response depended on the external sodium and calcium levels. 4 Procaine antagonized ACh effects with the same efficiency as atropine or hexamethonium, half maximal depression being obtained at a concentration of 10 −4 m . The blocking effect was independent of the dose of ACh. 5 The depression of the ACh‐induced depolarization by cobalt ions and D600 suggests that calcium may participate in this response.