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PRESYNAPTIC REGULATION OF THE RELEASE OF ACETYLCHOLINE BY 5‐HYDROXYTRYPTAMINE
Author(s) -
HIRAI K.,
KOKETSU K.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb08729.x
Subject(s) - acetylcholine , bullfrog , chemistry , motor nerve , neurotransmission , neuromuscular junction , cholinergic , endocrinology , serotonin , neuromuscular transmission , biophysics , neuroscience , medicine , biology , biochemistry , receptor
1 The effect of 5‐hydroxytryptamine (5‐HT) on the release of acetylcholine (ACh) from bullfrog sympathetic preganglionic nerve terminals and frog sciatic nerve terminals was studied with intracellular microelectrodes. 2 The change in transmitter release was measured from the mean quantal content calculated by the variance method from evoked fast e.p.s.ps or e.p.ps in low Ca 2+ ‐high Mg 2+ Ringer solution. 3 5‐HT facilitated the release of ACh in low concentrations and depressed it in relatively high concentrations at both preganglionic and motor nerve terminals. 4 These results suggest the possibility that 5‐HT may play a role in regulating cholinergic transmission in general.