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REGULATION OF NORADRENALINE OVERFLOW IN RAT CEREBRAL CORTEX BY PROSTAGLANDIN E 2
Author(s) -
HILLIER KEITH,
TEMPLETON WILMA W.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb08725.x
Subject(s) - prostaglandin e2 , prostaglandin , antagonist , cerebral cortex , medicine , chemistry , endocrinology , prostaglandin e2 receptor , norepinephrine , cortex (anatomy) , prostaglandin e , receptor antagonist , alpha (finance) , in vitro , receptor , pharmacology , neuroscience , biology , agonist , biochemistry , dopamine , construct validity , nursing , patient satisfaction
1 The effects of prostaglandin E 2 (PGE 2 ), PGF 2α and PGI 2 and of inhibitors of prostaglandin synthesis and action, on the K + ‐evoked [ 3 H]‐noradrenaline ([ 3 H]‐NA) overflow from rat cerebral cortex slices have been investigated. 2 PGE 2 reduced, while indomethacin (a prostaglandin synthesis inhibitor) or SC 19220 (a prostaglandin receptor antagonist) increased, the evoked overflow compared with controls. 3 The inhibition of [ 3 H]‐NA overflow by PGE 2 was dose‐dependently antagonized by SC 19220. 4 The results indicate that PGE 2 modulates NA release in rat cerebral cortex in vitro .