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THERMOREGULATORY EFFECTS OF N 6 ‐2′‐ O ‐DIBUTYRYL ADENOSINE 3′,5′‐MONOPHOSPHATE IN THE RESTRAINED MOUSE
Author(s) -
DASCOMBE M.J.,
MILTON A.S.,
NYEMITEIADDO I.,
PERTWEE R.G.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb08723.x
Subject(s) - rectal temperature , endocrinology , medicine , adenosine , chemistry , hypothermia , oxygen , respiration , thermoregulation , adenosine monophosphate , biology , anatomy , organic chemistry
1 The N 6 ‐2′‐ O ‐dibutyryl derivative of adenosine 3′,5′‐monophosphate (db cyclic AMP) has been micro‐injected into the third cerebral ventricle of the unanaesthetized, restrained mouse and the effects on body temperature and thermoregulatory activities observed. 2 Db cyclic AMP (4, 16 and 32 μg) injected intracerebroventricularly produced hypothermia when compared with temperature responses to sodium n ‐butyrate (6.8 μg). 3 Hypothermia induced by db cyclic AMP in mice was associated with a fall in oxygen consumption together with behavioural and autonomic heat loss activities but not cutaneous vasodilatation. The effects on rectal temperature and oxygen consumption were dose‐dependent. 4 The falls in rectal temperature and oxygen consumption induced by db cyclic AMP (4 μg) were decreased by elevation of the environmental temperature from 22 to 32°C and abolished at 36°C. 5 It is concluded db cyclic AMP may inhibit central events mediating the rise in metabolic heat production in mice upon exposure to cold environments.