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4‐AMINOPYRIDINE BLOCKADE OF NEURONAL DEPRESSANT RESPONSES TO ADENOSINE TRIPHOSPHATE
Author(s) -
PERKINS M.N.,
STONE T.W.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb08720.x
Subject(s) - adenosine , depressant , blockade , chemistry , adenosine triphosphate , purine , 4 aminopyridine , purine metabolism , pharmacology , glutamate receptor , neuroscience , biophysics , biochemistry , medicine , biology , receptor , potassium channel , enzyme
1 Adenosine, adenosine monophosphate and adenosine triphosphate (ATP) depressed the firing rate of neurones in the rat cerebral cortex when applied by microinontophoresis. 2 4‐Aminopyridine, also applied iontophoretically, blocked the depressant effects of the purines, without affecting responses to γ‐aminobutyric acid (GABA). This blockade was effected against purine depressions of both spontaneous and glutamate‐evoked activity, suggesting that the interaction occurred postsynaptically.