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FURTHER STUDIES ON OPIATE RECEPTORS THAT MEDIATE ANTI‐NOCICEPTION: TOOTH PULP STIMULATION IN THE DOG
Author(s) -
SKINGLE M.,
TYERS M.B.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07939.x
Subject(s) - nociception , morphine , opiate , stimulation , propoxyphene , analgesic , pharmacology , chemistry , nociceptor , opioid , anesthesia , medicine , receptor , endocrinology , biochemistry
1 The antinociceptive activities of morphine, codeine and dextropropoxyphene (μ‐agonists), buprenorphine and Mr 2034 [(‐)5,9‐dimethyl‐2‐(tetrahydrofurfuryl)‐2′‐hydroxy‐6,7‐benzomorphan](k‐agonists) have been determined against nociceptive responses to electrical stimulation of the tooth pulp in the conscious dog. 2 Dose‐dependent increases in nociceptive thresholds were obtained for all of the analgesic drugs tested at doses within their antinociceptive range as determined in nociceptive pressure and chemical tests in rodents.