Premium
INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS
Author(s) -
CHURCH MARTIN K.,
GRADIDGE CAROLYN F.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07919.x
Subject(s) - histamine , pharmacology , histamine n methyltransferase , chemistry , mepyramine , mast cell , histamine h4 receptor , potency , in vitro , histamine h1 receptor , histamine h2 receptor , monoamine oxidase , histamine receptor , receptor , antagonist , biochemistry , immunology , biology , enzyme
1 A series of cationic, lipophilic histamine H 1 ‐receptor antagonists, neuroleptics, antidepressants and monoamine oxidase inhibitors were tested for their effects on anti‐IgE‐induced histamine release from human lung fragments in vitro . 2 They had a biphasic effect: at low concentrations a dose‐related inhibition of histamine release was observed whereas, at higher concentrations, the drugs liberated histamine even in the absence of antigen. 3 Mepyramine, a much less lipophilic drug than the others tested, was only weakly active on mast cells at pharmacological concentrations. 4 The potency of the drugs as release inhibitors was not related quantitatively to their histamine liberating potency. 5 There was no correlation between activity on mast cells and histamine H 1 ‐receptor antagonism. 6 Mast cell stabilization may play a part in the activity of these drugs as Antiallergic agents.