Premium
INHIBITION OF REFLEX VAGAL BRADYCARDIA BY A CENTRAL ACTION OF 5‐HYDROXYTRYPTOPHAN
Author(s) -
TADEPALLI A.S.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07916.x
Subject(s) - bradycardia , reflex bradycardia , reflex , baroreceptor , vagus nerve , medicine , anesthesia , oculocardiac reflex , 5 hydroxytryptophan , endocrinology , heart rate , stimulation , serotonin , blood pressure , receptor
1 Vagally mediated reflex bradycardia was elicited in spinal cats with intravenous pressor doses of noradrenaline. Administration of 5‐hydroxytryptophan (1.5 and 3 mg total dose) into the fourth cerebral ventricle reduced the reflex bracycardia. 2 Inhibition of central amino acid decarboxylase with R044602 prevented the effects of 5‐hydroxytryptophan. After intravenous administration of 5‐hydroxytryptophan, vagal reflex bradycardia was not affected. 3 Results suggest that 5‐hydroxytryptophan acts in the CNS to inhibit baroreceptor‐mediated vagal reflex bradycardia and that action is mediated via conversion to 5‐hydroxytryptamine.