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EVALUATION OF THE ROLE OF HISTAMINE H 1 AND H 2 ‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION
Author(s) -
OWEN D.A.A.,
POY ELISABETH,
WOODWARD D.F.,
DANIEL D.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07912.x
Subject(s) - mepyramine , histamine , dimaprit , cimetidine , pharmacology , vascular permeability , histamine h1 receptor , mast cell , histamine h2 receptor , pyrilamine , histamine h4 receptor , degranulation , agonist , histamine receptor , chemistry , vasodilation , histamine h1 antagonists , endocrinology , medicine , receptor , immunology , antagonist
1 The role of histamine H 1 and H 2 ‐receptors in mediating the cutaneous inflammatory response produced by exogenous histamine and the release of endogenous histamine from mast cells has been investigated by a method which permits simultaneous, quantitative measurement of vasodilatation, vascular permeability and oedema formation. 2 Histamine and the selective H 1 ‐receptor agonist, 2‐(2‐aminoethyl) pyridine, both produced vasodilatation, increased vascular permeability and oedema formation whereas the selective H 2 ‐receptor agonist, dimaprit, produced only vasodilatation. 3 Mepyramine and cimetidine both reduced the vasodilatation response to histamine, the combination of antagonists being superior to either antagonist alone. Mepyramine (but not cimetidine) virtually abolished extravascular albumin accumulation and oedema formation. 4 Mepyramine and cimetidine both reduced the vasodilatation response produced by active cutaneous anaphylaxis and compound 48/80. However, mepyramine was less effective in reducing the vascular permeability response to mast cell degranulation than to histamine. 5 In conclusion, the vasodilator response to histamine is mediated by both H 1 ‐ and H 2 ‐receptors; the permeability response to histamine is mediated solely by H 1 ‐receptors. A combination of H 1 ‐ and H 2 ‐receptor antagonists appears to be more effective than either antagonist alone in reducing cutaneous inflammatory reactions involving histamine.