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FACILITATION OF SYMPATHETIC NEUROTRANSMISSION IN THE RAT ANOCOCCYGEUS MUSCLE BY PROSTAGLANDINS D 2 AND F 2α
Author(s) -
BEDWANI J.R.,
HILL SIAN E.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07911.x
Subject(s) - facilitation , neurotransmission , sympathetic nervous system , endocrinology , medicine , neuroscience , chemistry , biology , blood pressure , receptor
1 Investigations were made into the effects of prostaglandins D 2 (PGD 2 ) and F 2α (PGF 2α ) on the responses of the rat anococcygeus muscle to field stimulation of intrinsic motor (sympathetic) and inhibitory nerves, and to exogenous noradrenaline. 2 PGD 2 (2.8 × 10 −6 mol/1) substantially increased the motor responses to field stimulation at all frequencies tested (2 to 32 Hz), and caused a smaller increase in the responses to noradrenaline. 3 PGF 2α (2.8 × 10 −6 mol/1) strongly potentiated the motor responses to field stimulation (2 to 32 Hz) and also to noradrenaline. This prostaglandin had quantitatively similar effects on the responses to both types of stimulus. 4 PGD 2 was without effect on the inhibitory responses evoked by field stimulation in the presence of guanethidine. PGF 2α seemed to reduce the inhibitory responses to low frequencies of stimulation (0.5 to 1.5 Hz), but this effect was marginal. 5 The results suggest that PGD 2 facilitates sympathetic neurotransmission in this tissue by both pre‐ and post‐junctional actions. The effect of PGF 2α seems likely to be mediated predominantly post‐junctionally.