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CORONARY VASODILATATION: INTERACTIONS BETWEEN PROSTACYCLIN AND ADENOSINE
Author(s) -
BLASS K.E.,
FÖRSTER W.,
ZEHL U.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07903.x
Subject(s) - aminophylline , adenosine , coronary vasodilator , vasodilation , prostacyclin , theophylline , perfusion , medicine , coronary circulation , endocrinology , antagonist , chemistry , adenosine receptor antagonist , coronary vessel , adenosine receptor , pharmacology , blood flow , receptor , agonist
1 The influence of prostacyclin (PGI 2 ) on the release of adenosine in rabbit hearts perfused by the Langendorff method was examined under normal conditions of perfusion and during perfusion with the adenosine antagonist, aminophylline. 2 PGI 2 increased both coronary flow and the myocardial release of adenosine in a dose‐dependent manner. Aminophylline at a low concentration (10 μg/ml) suppressed the enhanced flow. 3 Adenosine increased both coronary flow and the release of PGI 2 from the isolated hearts; both these effects were inhibited by the low aminophylline concentration. Inhibition of PGI 2 ‐biosynthesis by 75% caused only a nonsignificant reduction in the adenosine‐induced enhancement of coronary flow. 4 Aminophylline at a high concentration (50 μg/ml) produced an increase in coronary flow and in release of PGI 2 as did adenosine; neither of these effects was observed with the low concentration of aminophylline (10 μg/ml). 5 It is suggested that the coronary vasodilator effects of PGI 2 in the isolated perfused rabbit hearts are due, at least partially, to the release of adenosine.