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THE EFFECT OF CONDITIONS INFLUENCING ENDOGENOUS PROSTAGLANDINS ON THE ACTIVITY OF Δ′‐TETRAHYDROCANNABINOL IN MICE
Author(s) -
FAIRBAIRN J.W.,
PICKENS JOAN T.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07039.x
Subject(s) - endogeny , tetrahydrocannabinol , pharmacology , chemistry , δ9 tetrahydrocannabinol , prostaglandin antagonist , endocannabinoid system , prostaglandin , neuroscience , endocrinology , cannabinoid , biology , biochemistry , receptor
1 The cataleptic effect of Δ′‐tetrahydrocannabinol (THC) depends upon the availability of the precursors of prostaglandins and the response is reduced in mice maintained on a diet deficient in arachidonic acid (AA) and restored by exogenous AA given intraperitoneally, or by feeding a normal diet. 2 In yeast‐induced fever, which is accompanied by an increase in the synthesis of prostaglandins, THC shows an enhanced cataleptic effect. 3 Exposure to cold which results in depletion of prostaglandins reduces the effect of THC.