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ANTIGEN‐INDUCED BRONCHIAL ANAPHYLAXIS IN ACTIVELY SENSITIZED GUINEA‐PIGS: ANTI‐ANAPHYLACTIC EFFECTS OF SODIUM CROMOGLYCATE AND AMINOPHYLLINE
Author(s) -
ANDERSSON PER
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07036.x
Subject(s) - aminophylline , ovalbumin , sensitization , anaphylaxis , histamine , medicine , pharmacology , bronchospasm , bronchodilator , cromolyn sodium , immunology , allergy , asthma , antigen , anesthesia
1 The inhibitory effects of sodium cromoglycate (SCG) and aminophylline on antigen‐induced bronchial anaphylaxis in guinea‐pigs, actively sensitized according to different regimens, were examined. 2 SCG (1 mg/kg administered intravenously) reduced the anaphylactic response in animals sensitized with 1 μg ovalbumin (OA) together with Al(OH) 3 100 mg, and challenged at 14 and 40 days after sensitization. If higher doses of antigen (10 μg OA together with Al (OH) 3 or 5 mg OA on day 0 plus 10 mg OA on day 2) were used for sensitization, the protective effect of SCG was found only in animals tested 14 days after sensitization. 3 A low dose of aminophylline (0.3 mg/kg) that was without a direct bronchodilator effect when tested against a histamine (4 μg/kg)‐induced bronchospasm, produced an anti‐anaphylactic effect. The anti‐anaphylactic effect of aminophylline varied slightly with the way the animals were immunized and the time at which they were tested. 4 It is concluded that bronchial anaphylaxis in guinea‐pigs sensitized with low doses of ovalbumin is a suitable model for the evaluation of anti‐anaphylactic properties of drugs.