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BLOCKADE BY YOHIMBINE OF PRAZOSIN‐RESISTANT PRESSOR EFFECTS OF ADRENALINE IN THE PITHED RAT
Author(s) -
FLAVAHAN N.A.,
McGRATH J.C.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb07021.x
Subject(s) - yohimbine , prazosin , blockade , epinephrine , medicine , endocrinology , pharmacology , anesthesia , antagonist , receptor
In the pithed rat, following β‐adrenoceptor blockade, the pressor effect of adrenaline can be blocked by phentolamine or by prazosin plus yohimbine but not by prazosin or yohimbine given alone. It is concluded that adrenaline produces its pressor effect by acting on two sets of post‐junctional α‐adrenoceptors, each of which is sensitive to phentolamine, one of which is sensitive to prazosin but resistant to yohimbine and the other of which is sensitive to yohimbine but resistant to prazosin.