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THE EFFECTS OF OPIATE RECEPTOR AGONISTS AND ANTAGONISTS ON THE STRESS‐INDUCED SECRETION OF CORTICOSTERONE IN MICE
Author(s) -
GIBSON A.,
GINSBURG M.,
HALL M.,
HART S.L.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb17342.x
Subject(s) - (+) naloxone , morphine , naltrexone , chemistry , opiate , corticosterone , pharmacology , endocrinology , levorphanol , pentazocine , medicine , opioid , receptor , biochemistry , hormone
1 Intraperitoneal administration of normorphine, morphine or naloxone or exposure to ethervapour for 1 miri, elevated plasma corticosteroid concentrations in mice. 2 Injection of saline or exposure to ether vapour rendered mice less sensitive to a subsequent exposure to ether vapour 15 min later. 3 Treatment with normorphine (50 mg/kg) potentiated the corticosteroid response to ether stress whilst pentazocine (20 mg/kg), naltrexone (10 mg/kg), morphine (24 mg/kg), levorphanol (20 mg/kg) and naloxone (50 mg/kg) prevented the stress‐induced elevation of plasma corticosteroids. 4 Both naloxone and morphine inhibited the potentiation by normorphine of the response to ether, the dose of naloxone required being higher than that for inhibition of normorphine analgesia. 5 It is concluded that endogenous opioid peptides may be involved in the control of the response to ether stress in mice.