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THE EFFECTS OF DEPRIVATION OF PROSTAGLANDIN PRECURSORS ON VASCULAR SENSITIVITY TO ANGIOTENSIN II AND ON THE KIDNEY IN THE PREGNANT RABBIT
Author(s) -
O'BRIEN P.M. SHAUGHN,
PIPKIN FIONA BROUGHTON
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb17330.x
Subject(s) - angiotensin ii , kidney , prostaglandin , renin–angiotensin system , rabbit (cipher) , endocrinology , medicine , chemistry , pharmacology , blood pressure , statistics , mathematics
1 Pregnant rabbits were deprived of essential fatty acids from day ten of pregnancy, and results compared with a control group on a normal diet. 2 At term, cannulation of jugular and carotid vessels was performed under anaesthesia, to study the vascular sensitivity to angiotensin II and basal blood pressure. 3 Plasma renin levels, urinary electrolytes and protein were measured. 4 Placental and renal tissue was examined histologically. 5 Though no changes were found in tissues, blood or urine, a markedly significant increase in response to angiotensin II was found in the group deprived of essential fatty acids. This parallels the findings in vascular response in human pre‐eclampsia.