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CALCIUM REQUIREMENTS FOR ELECTRICALLY‐INDUCED RELEASE OF AN ENDOGENOUS OPIATE RECEPTOR LIGAND FROM THE GUINEA‐PIG ILEUM
Author(s) -
OKA TETSUO,
SAWA AIKO
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb17326.x
Subject(s) - calcium , myenteric plexus , ileum , chemistry , opiate , endocrinology , guinea pig , medicine , stimulation , contraction (grammar) , receptor , endogeny , (+) naloxone , muscle contraction , biophysics , pharmacology , biochemistry , antagonist , biology , immunohistochemistry
Calcium requirements for electrically‐induced release of an endogenous opiate receptor ligand in the myenteric plexus‐longitudinal muscle strip of the guinea‐pig ileum were studied. The naloxone‐reversible depression of the electrically evoked contraction caused by stimulation at 10 Hz in normal Krebs solution was markedly reduced by decreasing the calcium concentration in the solution. The depression was greatly diminished by increasing the magnesium concentration in the solution. These results show that the electrically‐induced release of an opiate‐like material requires calcium ions.