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THE EFFECTS OF NEUROLEPTICS WITH CENTRAL DOPAMINE AND NORADRENALINE RECEPTOR BLOCKING PROPERTIES IN THE l ‐DOPA AND (+)‐ AMPHETAMINE‐INDUCED WAKING EEG IN THE RAT
Author(s) -
MONTI J.M.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb16110.x
Subject(s) - pimozide , amphetamine , dopamine , haloperidol , dopamine receptor , endocrinology , chemistry , pharmacology , medicine , dopaminergic , receptor , catecholamine
1 A study was carried out in rats (prepared for chronic sleep recording) of the effects of pretreatment with neuroleptics differing in their relative antinoradrenaline and antidopamine receptor potencies, on the l ‐DOPA and (+)‐amphetamine‐induced increase in waking EEG. 2 Haloperidol (0.6 mg/kg), which blocks central dopamine and noradrenaline (NA) receptors, reversed the EEG desynchronizing actions of l ‐DOPA and (+)‐amphetamine. 3 Low doses of pimozide (0.4 to 0.8 mg/kg) which block dopamine receptors exclusively, were not able to modify the pharmacologically induced disruption of the sleep‐awake cycle. However, at 1 mg/kg, a dose which also produces blockade of NA receptors, pimozide counteracted the increase in waking elicited by (+)‐amphetamine. 4 Spiroperidol (1 to 4 mg/kg) which is devoided of NA receptor blocking properties, failed to reverse the l ‐DOPA or (+)‐amphetamine‐induced arousal. 5 Our results suggest that the increased waking time observed after the catecholamine agonists is related to an increased availability of NA rather than dopamine.