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A COMPARISON OF THE ABILITIES OF ACETYLSALICYLIC ACID, FLURBIPROFEN AND INDOMETHACIN TO INHIBIT THE RELEASE REACTION AND PROSTAGLANDIN SYNTHESIS IN HUMAN BLOOD PLATELETS
Author(s) -
COCKBILL S.R.,
HEPTINSTALL S.,
TAYLOR PATRICIA M.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb16108.x
Subject(s) - flurbiprofen , arachidonic acid , chemistry , platelet , pharmacology , aspirin , in vitro , prostaglandin , adenosine diphosphate , prostaglandin e , cyclooxygenase , biochemistry , platelet aggregation , enzyme , medicine
1 A quantitative comparison has been made of the abilities of acetylsalicylic acid, flurbiprofen and indomethacin to inhibit the adenosine diphosphate (ADP)‐induced platelet release reaction and to inhibit the synthesis of prostaglandins from arachidonic acid. 2 Experiments were carried out on human platelets that had been incubated with the agents in vitro and on platelets obtained from volunteers who had ingested standard doses of the drugs. 3 The results obtained for acetylsalicylic acid show that there is a close relation between the release reaction and the synthesis of prostaglandins in platelets. 4 Flurbiprofen and indomethacin appear to inhibit the release reaction rather more effectively than they inhibit the synthesis of prostaglandins. It is possible that these agents inhibit the release reaction by another mechanism.