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ACETYLCHOLINE RECEPTORS IN THE CILIARY GANGLION AND IN THE IRIS MUSCLE OF THE CHICK: SPECIFIC BINDING AND EFFECT ON THE SYNAPTIC TRANSMISSION OF THE NEUROTOXIN FROM Naja naja siamensis
Author(s) -
CONTITRONCONI B.,
GOTTI C.,
PAGGI P.,
ROSSI A.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb16094.x
Subject(s) - ciliary ganglion , neurotoxin , acetylcholine , acetylcholine receptor , ganglion , sympathetic ganglion , biology , cholinergic , population , receptor , ganglion type nicotinic receptor , nicotinic acetylcholine receptor , anatomy , endocrinology , biochemistry , medicine , environmental health
1 A specific binding of Naja naja siamensis neurotoxin was found both in the iris and in the ciliary ganglion of the chick. 2 Naja‐toxin (125 n m ) caused a complete block of the iris muscle contraction induced by carbamyl‐choline. 3 Naja‐toxin had a different effect on the two neuronal populations present in the ganglion: it blocked the synaptically evoked response of the ciliary cells, while the response of the choroid ones was only slightly reduced. The effects were the same in a wide range of concentrations (125 to 2500 n m ). 4 The results obtained in the iris show the existence of an acetylcholine receptor population similar to the nicotinic receptor of the skeletal muscle. 5 In the ciliary ganglion the results confirm the existence of different acetylcholine receptors on the two cell types.