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BACKWARD WALKING AND CIRCLING: BEHAVIOURAL RESPONSES INDUCED BY DRUG TREATMENTS WHICH CAUSE SIMULTANEOUS RELEASE OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE
Author(s) -
CURZON G.,
FERNANDO J.C.R.,
LEES A.J.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb13696.x
Subject(s) - fenfluramine , amphetamine , licking , dextroamphetamine , dopamine , serotonin , p chloroamphetamine , hallucinogen , medicine , endocrinology , catecholamine , dopaminergic , pharmacology , chemistry , psychology , anesthesia , serotonergic , receptor
1 The roles of catecholamine and 5‐hydroxytryptamine (5‐HT) release in mediating backward walking and circling were studied in rats. 2 These behaviours occurred in animals given 15mg/kg intraperitoneally of (+)‐amphetamine (which predominantly releases catecholamines) or either p ‐chloroamphetamine or fenfluramine (which predominantly release 5‐HT). They also occurred when smaller doses of (+)‐amphetamine (5mg/kg) and either p ‐chloroamphetamine (2–5 mg/kg) or fenfluramine (5 mg/kg) were given together. 3 Characteristic dopamine‐dependent behaviours (rearing, licking, gnawing) resulting from (+)‐amphetamine injection were greatly reduced by p ‐chloroamphetamine or fenfluramine. 4 Characteristic 5‐HT‐dependent behaviours (wet dog shake, hind limb abduction) resulting from injection of either p ‐chloroamphetamine or fenfluramine were unaffected by (+)‐amphetamine. 5 Fragmentary backward walking and circling resulting from levallorphan injection (50 mg/kg s.c.) were decreased by (+)‐amphetamine at low dosage. 6 Results in general strengthen previous evidence that backward walking and circling are mediated by simultaneous dopamine and 5‐HT release. 7 The possible relevance of the above findings to hallucinogenic activity, amphetamine psychosis, schizophrenia and abnormal movements due to l ‐DOPA treatment is discussed.