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NORADRENALINE RELEASE IN RATS DURING PROLONGED COLD‐STRESS AND REPEATED SWIM‐STRESS
Author(s) -
BENEDICT C.R.,
FILLENZ MARIANNE,
STANFORD CLARE
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb13689.x
Subject(s) - cold stress , endocrinology , medicine , norepinephrine , chemistry , normetanephrine , catecholamine , plasma concentration , anesthesia , dopamine , biochemistry , gene
1 Plasma noradrenaline concentration in rats was measured during prolonged cold‐stress and repeated swim‐stress. 2 Cold exposure for 6 h caused a rise in plasma noradrenaline which reached a peak at 4 h. 3 Administration of desmethylimipramine and normetanephrine to block neuronal and extraneuronal uptake of noradrenaline raised plasma noradrenaline concentration without changing the pattern of the response to cold exposure. 4 Repeated cold exposure on subsequent days produced no change in the pattern of plasma noradrenaline concentration. 5 Five successive 1‐min swims at 30‐min intervals caused a rise in plasma noradrenaline concentration which was maximal after the third swim. 6 It is suggested that prolonged and repeated activation of sympathetic nerve terminals leads to a decline in noradrenaline release.