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RELATIONSHIP BETWEEN ACCUMULATION, STORAGE AND OVERFLOW OF NORADRENALINE IN THE RAT SALIVARY GLAND AFTER CHRONIC TREATMENT WITH GUANETHIDINE
Author(s) -
KHAN MOHAMMAD T.,
WAKADE ARUN R.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb13669.x
Subject(s) - guanethidine , salivary gland , submandibular gland , norepinephrine , medicine , endocrinology , chemistry , stimulation , dopamine
1 The effect of guanethidine on the endogenous noradrenaline (NA) content, accumulation and overflow of [ 3 H]‐noradrenaline ([ 3 H]‐NA) in the rat salivary gland was examined at various times after drug administration. 2 Twenty‐four h after a single injection of guanethidine (1 or 10 mg/kg s.c), the respective values for the endogenous NA content and for the accumulation and overflow of [ 3 H]‐NA were approximately 55, 85, 30%, and 15, 55, 10% of the controls. 3 Although [ 3 H]‐NA accumulation had returned to control levels within 48 h after the dose of 10 mg/kg guanethidine, the overflow of [ 3 H]‐NA evoked by electrical stimulation or excess potassium (K + ) remained depressed. 4 After the low or the high dose of guanethidine, the NA content of the salivary gland was restored to about 50% of the normal value between 4 to 24 and 48 to 72 h, respectively. 5 The accumulation of [ 3 H]‐NA was inhibited by about 75% by cocaine. The same degree of inhibition was obtained 4 h after 10 mg/kg guanethidine. In these experiments phenoxybenzamine did not reduce the residual (25%) uptake. 6 The reasons for differential rates of recovery of the endogenous NA content and the storage of [ 3 H]‐NA after guanethidine are discussed.