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EVIDENCE FOR AN INDIRECT CHOLINERGIC REGULATION OF BLOOD FLOW IN THE HYPOTHALAMUS OF CONSCIOUS RABBITS
Author(s) -
KLUGMAN K.,
MITCHELL G.,
ROSENDORFF G.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb13668.x
Subject(s) - methacholine , phenoxybenzamine , atropine , propranolol , endocrinology , medicine , muscarinic acetylcholine receptor , vasodilation , cholinergic , hypothalamus , physostigmine , chemistry , phentolamine , receptor , respiratory disease , lung
1 The effects of methacholine, atropine and adrenoceptor blockade on hypothalamic blood flow (HBF) were measured in conscious rabbits. 2 A dose of 1 μg methacholine increased HBF while smaller and larger doses had no significant effect. 3 The vasodilatation induced by methacholine was blocked by atropine and by chemical sympathectomy of the hypothalamus with 6‐hydroxydopamine. 4 The vasodilatation was reversed by propranolol but was not affected by phenoxybenzamine. 5 These results suggest that the vasodilator action of muscarinic receptor agonists on hypothalamic resistance vessels depends upon the integrity of a noradrenergic system, and is mediated via β‐adrenoceptors.