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THE EFFECTS OF H 1 ‐ AND H 2 ‐RECEPTOR AGONISTS AND ANTAGONISTS ON TOTAL LUNG RESISTANCE, DYNAMIC LUNG COMPLIANCE AND IRRITANT RECEPTOR DISCHARGE IN THE ANAESTHETIZED DOG
Author(s) -
DIXON M.,
JACKSON D.M.,
RICHARDS I.M.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb13666.x
Subject(s) - cimetidine , histamine , histamine h2 receptor , chemistry , lung , pharmacology , receptor , histamine h1 receptor , pulmonary compliance , airway resistance , anesthesia , medicine , antagonist , biochemistry
1 The effects of histamine and 4 methylhistamine (i.v.) alone, and in the presence of chlorpheniramine or cimetidine, on total lung resistance (R L ), dynamic lung compliance (C dyn ) and irritant receptor activity have been studied in dogs anaesthetized with chloralose. 2 Histamine produced dose‐related increases in R L and irritant receptor activity with associated falls in C dyn which were blocked by chlorpheniramine but unaffected by cimetidine. 3 4 Methylhistamine produced small insignificant changes in R 1 and C dyn and small significant increases in irritant receptor activity which were reduced with chlorpheniramine but unaffected by cimetidine. 4 The results suggest that histamine increases irritant receptor activity, either directly or indirectly, via H 1 ‐receptors.