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THE ACTIONS OF 5‐HYDROXYTRYPTAMINE AND HISTAMINE ON THE ISOLATED ILEUM OF THE TREE SHREW ( Tupaia glis )
Author(s) -
SAKAI K.,
SHIRAKI Y.,
TATSUMI T.,
TSUJI K.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb10845.x
Subject(s) - methysergide , ileum , histamine , hexamethonium , atropine , tetrodotoxin , diphenhydramine , medicine , endocrinology , biology , guinea pig , serotonin , pharmacology , chemistry , receptor
1 Contractions to 5‐hydroxytryptamine (5‐HT) and histamine of longitudinal muscle from the isolated ileum of the tree shrew ( Tupaia ), guinea‐pig and rat were investigated by constructing dose‐response curves and studying the effects of various antagonists. 2 In the Tupaia and rat ileum the contraction to 5‐HT was reduced by methysergide but not affected by tetrodotoxin (TTX), morphine, hexamethonium (C 6 ) or atropine. The response of guinea‐pig ileum to 5‐HT was not significantly inhibited by methysergide or C 6 , but was blocked by TTX, morphine and atropine. 3 Histamine‐induced contraction of Tupaia and guinea‐pig ileum was antagonized by diphenhydramine but not by TTX, morphine, C 6 or atropine. Histamine was almost without effect on the rat ileum.