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INVOLVEMENT OF SRS‐A IN THE SCHULTZ‐DALE RESPONSE OF THE GUINEA‐PIG SMALL INTESTINE
Author(s) -
HERMAN A.G.,
LAEKEMAN G.M.,
BEEK H.A.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb10842.x
Subject(s) - mepyramine , contraction (grammar) , ovalbumin , guinea pig , ileum , chemistry , antagonist , antigen , medicine , endocrinology , biophysics , biology , biochemistry , immunology , receptor
1 The anaphylactic reaction of the guinea‐pig ileum, the so called Schultz‐Dale reaction, shows a biphasic response: a short rapid contraction followed by a partial relaxation and a slow contractile response. 2 Dose‐response curves with ovalbumin as an antigen were obtained for the quick and slow contraction of this anaphylactic reaction. 3 Mepyramine (1 μg/ml) blocked the rapid first contraction, but failed to abolish the slow one in about 50% of the animals studied. 4 The SRS‐A antagonist, FPL 55712, significantly depressed the slow sustained contraction during the Schultz‐Dale reaction. Disodiumcromoglycate was without effect on both phases when it was added 5 min before addition of the antigen. However, when added simultaneously with the antigen it produced a 30% suppression of the slow phase in the highest concentration used.