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NALOXONE INHIBITS THE ANTI‐DIARRHOEAL ACTIVITY OF LOPERAMIDE
Author(s) -
PIERCEY M.F.,
RUWART M.J.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb10840.x
Subject(s) - loperamide , antidiarrhoeal , (+) naloxone , opiate , medicine , pharmacology , prostaglandin , diarrhoeal disease , diarrhea , endocrinology , receptor , antagonist , chemistry , biochemistry , castor oil
1 Subcutaneous prostaglandin E 2 (2.5 mg/kg) produces profuse diarrhoea in fed rats. 2 Pretreatment of rats with subcutaneous loperamide (1.0 mg/kg) completely prevents prostaglandin‐induced diarrhoea. If naloxone is administered prior to loperamide injections the activity. of the antidiarrhoeal compound is completely destroyed. 3 These data provide strong evidence that the antidiarrhoeal activity of loperamide is mediated via the opiate receptor.