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PHARMACOLOGICAL EFFECTS OF PHOSPHATIDYLSERINE LIPOSOMES: THE ROLE OF LYSOPHOSPHATIDYLSERINE
Author(s) -
BIGON E.,
BOARATO E.,
BRUNI A.,
LEON A.,
TOFFANO G.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb08708.x
Subject(s) - phosphatidylserine , liposome , phospholipid , phospholipase a2 , phosphatidylethanolamine , biochemistry , incubation , chemistry , biology , microbiology and biotechnology , biophysics , phosphatidylcholine , enzyme , membrane
1 Unique among the phospholipids, phosphatidylserine depresses brain energy metabolism when injected intravenously into mice in the form of sonicated liposomes. The possibility that this effect results from a metabolic transformation of phosphatidylserine is examined in this paper. 2 A strong enhancement of the phosphatidylserine effect is induced by the incubation of liposomes with rat serum. Similar phosphatidylserine activation is observed after the incubation of the phospholipid with purified phospholipase A 2 from pancreas. In both cases phosphatidylserine is split into the deacylated derivative, lysophosphatidylserine. 3 Lysophosphatidylserine reproduces with greater efficacy the effect of phosphatidylserine on brain energy metabolism. Other lysophospholipids are not effective. 4 It is concluded that the pharmacological effects of phosphatidylserine liposomes is due to the generation of lysophosphatidylserine.