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A PHARMACOLOGICAL ANALYSIS OF THE CONTRACTILE ACTION OF HISTAMINE UPON THE ILEAL REGION OF THE ISOLATED, BLOOD‐PERFUSED SMALL INTESTINE OF THE RAT
Author(s) -
SAKAI K.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb08705.x
Subject(s) - hexamethonium , histamine , ileum , contraction (grammar) , mepyramine , tetrodotoxin , atropine , myenteric plexus , cholinergic , small intestine , chemistry , medicine , muscle contraction , superior mesenteric artery , endocrinology , anatomy , biology , antagonist , receptor , immunohistochemistry
1 The mode of action of histamine was investigated on the rat isolated small intestine perfused at a fixed flow rate through the superior mesenteric artery with blood from the carotid artery of a heparinized donor rat. Compounds were closely injected into the superior mesenteric artery. 2 Increasing doses (1 to 100 μg) of histamine caused a monophasic fast contraction of the ileum. 3 The fast contraction was abolished by tetrodotoxin, hexamethonium, morphine or mepyramine, but was not prevented by atropine. 4 The present study indicates that histamine produces the fast contraction of the ileum by primarily acting on the myenteric nerve plexus involving cholinergic interneurones.