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EFFECTS OF UPTAKE INHIBITORS ON RESPONSES OF SHEEP CORONARY ARTERIES TO CATECHOLAMINES AND SYMPATHETIC NERVE STIMULATION
Author(s) -
BRINE F.,
CORNISH E.J.,
MILLER R.C.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb08701.x
Subject(s) - stimulation , medicine , endocrinology , desipramine , catecholamine , isoprenaline , guanethidine , chemistry , metaraminol , norepinephrine , dopamine , antidepressant , blood pressure , hippocampus
1 Transmural stimulation of intrinsic sympathetic nerves and exogenous catecholamines produce β 1 ‐adrenoceptor mediated relaxant responses in strips of contracted sheep coronary artery. 2 The neuronal uptake inhibitors, metaraminol, cocaine and desipramine and the extraneuronal uptake inhibitor, cortisol, failed to potentiate responses to noradrenaline or sympathetic stimulation; responses to isoprenaline were enhanced by cortisol. 3 Oxytetracycline, which inhibits binding to connective tissue fibres, did not affect responses to noradrenaline or nerve stimulation. 4 17β‐Oestradiol, caffeine and U0521 proved to be unsuitable compounds for studying catecholamine inactivation since they non‐selectively potentiated responses to noradrenaline and isoprenaline. 5 It is concluded that catecholamine inactivation processes do not modify transmitter function in sheep coronary arteries.