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THE SUBDIVISION OF β‐ADRENOCEPTORS IN THE CARDIOVASCULAR SYSTEM OF THE RAT
Author(s) -
IMMS F.J.,
NEAME R.L.B.,
POWIS D.A.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb08689.x
Subject(s) - practolol , propranolol , isoprenaline , beta adrenoceptor , medicine , oxprenolol , endocrinology , vasodilation , adrenergic beta antagonists , pharmacology , beta (programming language) , adrenergic receptor , antagonism , chemistry , receptor , stimulation , computer science , programming language
1 The antagonism by the β‐adrenoceptor blocking drugs, propranolol (non‐selective) and practolol (β‐selective), of the cardiovascular actions of isoprenaline has been investigated in the rat. 2 All doses of practolol (0.1, 1 and 3 mg/kg) blocked the cardio‐accelerator action of isoprenaline but only the largest dose blocked the vasodilator effect. 3 All doses of propranolol (0.01, 0.03 and 0.1 mg/kg) blocked the vasodilator effect of isoprenaline but only the largest dose diminished the tachycardia. 4 It is concluded that in the rat, as in other species, β‐adrenoceptors may be subdivided into β 1 (cardiac) and β 2 (peripheral vascular) types.