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THYROTROPHIN RELEASING HORMONE STIMULATES RELEASE OF [ 3 H]‐DOPAMINE FROM SLICES OF RAT NUCLEUS ACCUMBENS in vitro
Author(s) -
KERWIN R.W.,
PYCOCK C.J.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb08682.x
Subject(s) - nucleus accumbens , dopamine , medicine , endocrinology , chemistry , caudate nucleus , spiperone , basal ganglia , nucleus , biology , central nervous system , neuroscience , dopamine receptor
Thyrotrophin releasing hormone (TRH) (25 to 100 μ m ) was found to stimulate the efflux of [ 3 H]‐dopamine from small slices of rat nucleus accumbens, but not from similar slices of rat caudate nucleus. Uptake inhibition was not responsible for this action, since at 10 and 50 μ m TRH had no effect on the ability of small slices of nucleus accumbens to accumulate radioactivity when incubated with 10 −7 m [ 3 H]‐dopamine. In addition the hormone had no effect on basal or dopamine‐stimulated adenylate cyclase, nor did it displace [ 3 H]‐spiperone binding, in membrane preparations from nucleus accumbens.