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INHIBITION OF INSULIN SECRETION FROM THE PERFUSED PANCREAS OF THE RAT BY PIZOTIFEN
Author(s) -
JOOST H.G.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb08675.x
Subject(s) - cyproheptadine , endocrinology , medicine , insulin , perfusion , pancreas , chemistry , serotonin , receptor
1 In the perfused rat pancreas the effects of pizotifen on insulin release induced by 20 m m glucose were studied. 2 Pizotifen (10 and 100 μ m ) significantly reduced the insulin release during a 25 min perfusion period to 49% and 7% of the controls. 3 The same concentrations of the structurally related agents cyproheptadine, doxepin, and chlorpromazine produced a comparable inhibition.