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CORONARY ANAPHYLAXIS in vitro
Author(s) -
CHAND N.,
EYRE P.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb08666.x
Subject(s) - anaphylaxis , in vitro , medicine , cardiology , chemistry , immunology , allergy , biochemistry
1 The reactivity of isolated coronary arteries and cardiac veins of the calf to selected chemical mediators of anaphylaxis and to sensitizing antigen (horse plasma) was studied. 2 Both the coronary arteries and cardiac veins contracted to bradykinin, 5‐hydroxytryptamine (5‐HT), prostaglandin E 2 (PGE 2 ), PGF 2α , histamine and carbachol. 3 Isoprenaline and PGE 1 relaxed vessels which had been partially contracted by PGF 2α , PGE 2 , histamine, 5‐HT, bradykinin, carbachol or antigen. 4 Horse plasma (antigen) contracted coronary vessels obtained from sensitized calves, but not from control calves. Subsequent antigen ‘challenge’ produced ‘desensitization’ (tachyphylaxis). After 1 or 2 h of rest, the anaphylactic response partially recovered although there was no change in tissue reactivity to the exogenous agonists. 5 Specific doses of atropine, mepyramine (H 1 ‐blocker) and methysergide (5‐HT antagonist) did not modify the anaphylactic reaction in coronary arteries, suggesting a negligible role for these biogenic amines. 6 Compound PRD‐92‐EA (a new anti‐allergic agent) exhibited non‐specific receptor blocking activity towards histamine, 5‐HT and carbachol and inhibited the coronary anaphylactic reaction.