Premium
THE PROTECTIVE EFFECT OF SOME PHENOTHIAZINE DERIVATIVES AGAINST STREPTOLYSIN O
Author(s) -
BESLUAU D.,
GAUTHIERRAHMAN S.,
HALPERN B.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb08663.x
Subject(s) - phenothiazine , promethazine , streptolysin , chlorpromazine , pharmacology , in vitro , chemistry , medicine , biochemistry , bacterial protein , gene
1 Chlorpromazine (Cpz) and promethazine (Pmz) protected mice against lethal doses of streptolysin O (SLO) given intravenously. Three other phenothiazine derivatives had similar but lesser effects. 2 The protective effect developed slowly; maximal protection was obtained 4 h after subcutaneous injection of Cpz and Pmz. 3 The haemolytic activity of SLO in vitro was also inhibited by Cpz.