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ASSESSMENT OF THE EFFECTS OF VASOACTIVE INTESTINAL PEPTIDE (VIP) ON BLOOD FLOW THROUGH AND SALIVATION OF THE DOG SALIVARY GLAND IN COMPARISON WITH THOSE OF SECRETIN, GLUCAGON AND ACETYLCHOLINE
Author(s) -
SHIMIZU T.,
TAIRA N.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07882.x
Subject(s) - secretin , vasoactive intestinal peptide , endocrinology , medicine , acetylcholine , vasodilation , tachyphylaxis , submandibular gland , atropine , saliva , chemistry , neuropeptide , pancreas , receptor
1 The vascular bed of the submandibular gland in situ was perfused with blood through the glandular artery at a constant pressure in anaesthetized dogs. All drugs were administered intra‐arterially. 2 Vasoactive intestinal peptide (VIP), secretin and acetylcholine produced a dose‐dependent increase in blood flow through the artery (vasodilatation) but glucagon was almost ineffective. 3 Dose‐blood flow response curves for VIP and secretin were parallel, and VIP was about 100 times as potent as secretin on a molar basis. Dose‐blood flow response curves for acetylcholine were flatter than those for VIP and secretin. Acetylcholine was approximately as potent as secretin on a molar basis. 4 No tachyphylaxis developed to the vasodilator action of VIP. 5 The vasodilator responses to VIP and to electrical stimulation of the chordolingual nerve were scarcely modified by (—)‐hyoscyamine in doses that fully antagonized the vasodilator response to acetylcholine. 6 VIP, secretin and glucagon were ineffective in eliciting salivary secretion. 7 The possibility that VIP is released from parasympathetic vasodilator nerves and mediates the atropine‐resistant vasodilatation in the dog submandibular gland is discussed.