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ON THE ROLE OF 5‐HYDROXYTRYPTAMINE IN DRUG‐INDUCED ANTINOCICEPTION
Author(s) -
SUGRUE M.F.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07881.x
Subject(s) - morphine , pethidine , pharmacology , methadone , chemistry , nociception , serotonin , analgesic , medicine , receptor , biochemistry
1 The effects of four specific inhibitors of 5‐hydroxytryptamine (5‐HT) uptake on morphine‐, methadone‐ or pethidine‐induced antinociception was studied in rats. Antinociception was assessed by means of hot plate (55°C) reaction times. The effect of the compounds on the uptake of [ 3 H]‐5‐HT into rat whole brain synaptosomes was also investigated. 2 Pretreatment with Org 6582, citalopram, zimelidine or femoxetine at doses devoid of antinociceptive activity potentiated morphine‐ but not methadone‐ or pethidine‐induced antinociception. 3 A temporal correlation existed between the ability of Org 6582 to potentiate morphine‐induced antinociception and to block synaptosomal [ 3 H]‐5‐HT uptake. 4 5‐HT plays a critical role in the antinociceptive effect of morphine but not of methadone or pethidine.