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EFFECTS OF CIGARETTE SMOKE ON THE METABOLISM OF VASOACTIVE HORMONES IN RAT ISOLATED LUNGS
Author(s) -
BAKHLE Y.S.,
HARTIALA J.,
TOIVONEN H.,
UOTILA P.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07857.x
Subject(s) - vasoactive , hormone , endocrinology , medicine , bradykinin , nicotine , smoke , cigarette smoke , metabolism , lung , chemistry , angiotensin ii , physiology , blood pressure , receptor , environmental health , organic chemistry
1 The effects of exposure of rats to cigarette smoke have been studied on the metabolism of vasoactive hormones in isolated lungs from these animals. 2 Rats were exposed for 1 h per day to cigarette smoke for 1 day or for 10 days. 3 Angiotensin I conversion was increased after 1 day's exposure but after 10 days' exposure conversion returned to normal. 4 Inactivation of prostaglandin E 2 was decreased after 1 day's exposure. After 10 days' exposure there was a further decrease which could not be attributed to smoke alone. 5 The inactivation of 5‐hydroxytryptamine and bradykinin remained unchanged after both short and longer exposures to smoke. 6 The metabolic activity of the lung towards some vasoactive hormones in the pulmonary circulation is affected by exposure of the animal to cigarette smoke and such changes may be relevant to the initiation of cardiovascular changes consequent upon cigarette smoking.