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ACTION OF COLCHICINE AND CYTOCHALASIN B ON THE ACETYLCHOLINE RECEPTOR
Author(s) -
ANWYL ROGER,
NARAHASHI TOSHIO
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07855.x
Subject(s) - colchicine , cytochalasin b , acetylcholine , cytochalasin , biophysics , chemistry , acetylcholine receptor , cytochalasin d , microfilament , mechanism of action , pharmacology , receptor , endocrinology , microbiology and biotechnology , medicine , biology , biochemistry , cytoskeleton , cell , in vitro
1 The effects of colchicine and cytochalasin B have been investigated on the extrajunctional acetylcholine (ACh) receptors of rat muscle. 2 Colchicine and cytochalasin B each decreased the amplitude and rise time of the iontophoretic ACh potential. When the dose of ACh was increased in the presence of these agents, ACh potentials were produced with a biphasic waveform consisting of a fast initial phase and a second slow phase. 3 It is proposed that colchicine and cytochalasin B are acting through a mechanism other than the breakdown of microtubules and microfilaments.