Premium
ON THE MECHANISM OF PANCURONIUM‐INDUCED SUPER‐SENSITIVITYTO NORADRENALINE IN RAT SMOOTH MUSCLE
Author(s) -
TOMLINSON D.R.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07853.x
Subject(s) - pancuronium bromide , vas deferens , reserpine , chemistry , agonist , medicine , endocrinology , norepinephrine , long term potentiation , anesthesia , receptor , dopamine
1 Pancuronium bromide (5 × 10 −5 m ) caused super‐sensitivityto noradrenaline in the rat isolated vas deferens and hepatic portal vein. This super‐sensitivitywas manifest as a parallel leftward shift of the dose‐response curve for noradrenaline with no alteration of the maximum response to the agonist. 2 Pancuronium did not potentiate the response of the vas and portal vein to St 91, anα‐adrenocep‐tor agonist which is not a substrate for Uptake x . 3 Pancuronium did not potentiate the response of the vas to CaCl 2 . 4 In vasa deferentia made supersensitive to noradrenaline by treatment with cocaine (1 × 10 −5 m ) pancuronium induced no further potentiation of the response to noradrenaline. However, the super‐sensitivityto noradrenaline induced by pancuronium alone was augmented by the addition of cocaine. 5 Histofluorescence studies showed that pancuronium inhibited neuronal uptake of α‐methyl noradrenaline in various noradrenergically‐innervated tissues from reserpine‐treated rats. 6 This study, with support from the literature, suggests that pancuronium induces noradrenaline super‐sensitivityby blockade of Uptake!.