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PROSTAGLANDIN BIOSYNTHESIS BY GUINEA‐PIG SKELETAL MUSCLE in vitro AND THE EFFECT OF OESTRADIOL‐17β AND PROGESTERONE
Author(s) -
KERRY P.J.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07849.x
Subject(s) - endocrinology , medicine , in vivo , guinea pig , microgram , radioimmunoassay , prostaglandin , skeletal muscle , prostaglandin e2 , biosynthesis , in vitro , chemistry , prostaglandin e , prostaglandins f , biology , biochemistry , enzyme , microbiology and biotechnology
1 The effect of oestradiol and progesterone on prostaglandin biosynthesis by guinea‐pig skeletal muscle in vitro has been investigated. 2 At high concentrations, oestradiol‐17β (100 μg/ml) and progesterone (500 μg/ml) increased prostaglandin E and prostaglandin F synthesis (measured by radioimmunoassay). 3 It is suggested that these steroids are unlikely to be found in vivo at levels sufficient to influence prostaglandin synthesis by skeletal muscle in physiological and pathological situations.