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β‐ADRENOCEPTOR BLOCKING DRUGS AND ISOPRENALINE: CENTRAL EFFECTS ON CARDIOVASCULAR PARAMETERS
Author(s) -
COHEN Y.,
LINDENBAUM A.,
MIDOLMONNET MICHELE,
PORQUET D.,
WEPIERRE J.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07842.x
Subject(s) - propranolol , pindolol , isoprenaline , heart rate , blood pressure , cardiac output , stroke volume , medicine , vascular resistance , anesthesia , cardiology , endocrinology , stimulation
1 The central hypotensive activity of (+)‐ and (—)‐propranolol (100 μg), pindolol (100 μg) and isoprenaline (1 and 4 μg) injected intracerebroventricularly (i.c.v.) was studied in rats anaesthetized with urethane and chloralose. Blood pressure, cardiac output and heart rate were measured; systolic stroke volume and peripheral vascular resistance were calculated. 2 (+)‐ and (—)‐Propranolol and pindolol induced a fall of blood pressure but (+)‐propranolol was less active. The heart rate was reduced more by (—)‐propranolol than by (+)‐propranolol or (—)‐pindolol. The decrease of systolic stroke volume was greater for (—)‐propranolol and pindolol than for (+)‐propranolol. Peripheral vascular resistance was reduced to the same level but with different time courses, (—)‐propranolol having a longer effect than (+)‐propranolol and pindolol. 3 Isoprenaline induced a hypotensive effect, while cardiac output and heart rate increased; the systolic stroke volume remained stable but peripheral vascular resistance was significantly decreased. 4 These results suggest that different central regulatory centres are involved in the control of cardiac function and peripheral vascular tone.