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ROLE OF 5‐HYDROXYTRYPTAMINE IN THE VASOCONSTRICTOR ACTION OF COMPOUND 48/80 IN THE RAT FEMORAL VASCULATURE
Author(s) -
SAKAI K.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07839.x
Subject(s) - vasoconstriction , methysergide , vasodilation , adenosine , reserpine , chemistry , pharmacology , medicine , endocrinology , serotonin , receptor
1 The effect of compound 48/80 on the rat femoral vasculature was examined by means of a cross‐circulation technique. 2 Intra‐arterial injection of increasing doses (1.5 to 15 ug) of compound 48/80 caused dose‐dependent vasoconstriction preceded by transient vasodilatation. The vasoconstriction was significantly reduced in reserpine‐treated preparations and converted to vasodilatation by methysergide. 3 When the vasoconstrictor response to a large dose (300 ug) of adenosine was abolished by repeated administration, the response to compound 48/80 remained unaltered. 4 The present results indicate that the femoral arterial vasoconstriction by compound 48/80 in the rat is mediated by the release of 5‐hydroxytryptamine (5‐HT); this 5‐HT may be liberated from a different storage site from that released by adenosine.