Premium
RELEASE OF PROSTAGLANDINS DURING CONTRACTION OF THE HUMAN UMBILICAL VEIN ON REDUCTION OF TEMPERATURE
Author(s) -
BOURA A.L.A.,
BOYLE LYNDALL,
SINNATHURAY T.A.,
WALTERS W.A.W.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07838.x
Subject(s) - umbilical vein , contraction (grammar) , umbilical cord , chemistry , vein , anesthesia , shivering , blood flow , endocrinology , fundus (uterus) , medicine , anatomy , surgery , biochemistry , in vitro
Flow rate was measured through the vein of the human isolated umbilical cord perfused at constant pressure (40 mmHg) at 37.5°C and 20°C. At the latter temperature the flow was decreased by 50.9% when compared with a mean of 201 ml/min at 37.5°C indicating veno‐spasm. Indomethacin (10 ug/g) effected a highly significant reduction in the venous spasm caused by lowering the temperature. After indomethacin pretreatment, changing the cord temperature from 37.5°C to 20°C caused a mean decrease in flow of only 3.1%. When the effluent from the vein was passed over rat isolated stomach fundus and colonic strips, cooling of the cord was accompanied by contractions of the isolated tissues characteristic of prostaglandins. These results suggest that prostaglandins are involved in temperature‐induced closure of the human umbilical vein after birth.
Discover
Journals
Proceedings
Books
Explore
Engineering & Computer Science
Health & Medical Sciences
Humanities, Literature & Arts
Life Sciences & Earth Sciences
Physics & Mathematics
Social Sciences
Chemical & Material Sciences
Business, Economics & Management