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PROSTAGLANDIN D 2 IS THE PREVAILING PROSTAGLANDIN IN THE ACUTE INFLAMMATORY EXUDATE OF URATE ARTHRITIS IN THE CHICKEN
Author(s) -
ANHUT HENNING,
BRUNE KAY,
FRÖLICH JURGEN C.,
PESKAR BERNHARD A.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07837.x
Subject(s) - exudate , prostaglandin d2 , prostaglandin , chemistry , inflammation , thromboxane b2 , radioimmunoassay , prostaglandin e2 , medicine , endocrinology , biochemistry , pathology , platelet
An acute inflammation was elicited in intertarsal joints of chicken by injection of urate crystals. Inflammatory exudates recovered at different times were assayed for prostaglandin D 2 (PGD 2 ) E 2 and F 2α and thromboxane B 2 content by specific radioimmunoassays. We found that PGD 2 was the prevailing prostaglandin reaching concentrations up to 10 times in excess of PGE 2 . This finding was confirmed by gas chromatography‐mass spectrometry. It is concluded that PGD 2 should be considered as a possible mediator of acute inflammation.