Premium
THE EFFECTS OF SOME HYDROPHOBIC GASES ON THE PULMONARY SURFACTANT SYSTEM
Author(s) -
DANIELS S.,
PATON W.D.M.,
SMITH E.B.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07823.x
Subject(s) - chemistry , pulmonary surfactant , atropine , halothane , nitrous oxide , anesthesia , organic chemistry , biochemistry , medicine
1 Decompression from exposures to raised ambient pressure of sulphur hexafluoride, carbon tetra‐fluoride, hexafluoro‐ethane and nitrous oxide results in the formation of dense foam and pulmonary oedema. 2 The degree of pulmonary oedema produced is dependent on the exposure pressure, although the exposure time required is short in comparison to tissue saturation times. 3 The effect is not prevented by atropine, ephedrine or hydrocortisone. 4 The effect is also produced in vitro by saturated solutions of halothane, chloroform and ether. 5 It is suggested that the mechanism of action is physical with the physico‐chemical factor involved being a differential partition of these gases within the surfactant: membrane complex.