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LACK OF RELEASE OF PROSTAGLANDINS FROM ISOLATED PER‐FUSED LUNGS DURING PULMONARY HYPERTENSION AND OEDEMA
Author(s) -
SCOTT ELIZABETH,
VAAGE J.,
WIBERG T.
Publication year - 1979
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1979.tb07819.x
Subject(s) - lung , pulmonary hypertension , guinea pig , prostaglandin , medicine , pulmonary artery , thromboxane b2 , thromboxane , circulatory system , prostaglandins f , anesthesia , blood pressure , endocrinology , platelet
1 The effects on pulmonary prostaglandin synthesis of pulmonary hypertension and oedema have been studied. 2 Seventeen isolated lungs of rabbit, cat and guinea‐pig were perfused with plasma, whole blood or Krebs Ringer solution in a recirculating system. 3 The venous effluent from the lungs superfused (10 ml/min) a series of smooth muscle tissues sensitive to prostaglandins and thromboxane A 2 ; these were: rat stomach strip, rat colon, chick rectum and rabbit aorta. 4 Left atrial pressure was increased by between 10 and 30 mmHg for periods of 3 to 59 minutes. Gross alveolar oedema eventually developed in all experiments. 5 Neither pulmonary hypertension nor subsequent oedema caused release of prostaglandins into the venous effluent.